Insulin (ins) Promoter Vntr Polymorphisms: Interactions and Association with Type 1 Diabetes Mellitus in Bengali Speaking Patients of Eastern India
نویسندگان
چکیده
West Bengal, India 2 Department of Biomedical Sciences, Sri Ramachandra University, Chennai 600 116, India 3 Department of Human Genetics, Andhra University, Visakhapatnam 530003, India 4 Endocrinology Department, SSKM Hospital, Kolkata, India 5 Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata, India 6 Department of Anthropology, University of Delhi, 110 007, Delhi, India Original Research Article
منابع مشابه
The Relationship between insulin variable number of tandem repeats (INS-VNTR) -23 A/T and cytotoxic T-lymphocyte associated protein-4 (CTLA-4) +49 A/G polymorphisms with islet autoantibodies in persons with diabetes
Background: Both genetic and environmental factors are important in pathogenesis of diabetes. Non HLA (Human Leukocyte Antigen) genes such as INS-VNTR and CTLA-4 in addition of HLA genes have influence on genetic susceptibility for diabetes mellitus. In this study the association of +49 A/G CTLA-4 and -23 A/T INS-VNTR polymorphisms with diabetes and their association with islet auto...
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BACKGROUND Human leukocyte antigens (HLA) complex and INS-IGF2 5'VNTR loci are principal determinants of the risk of type 1 diabetes mellitus (T1DM). Carriage of class III allele is protective, while class I/I homozygosity increases the risk of T1DM. MATERIAL AND METHODS HLA and 5'VNTR allele frequencies were summarised and multivariate logistic regression models with interaction evaluation w...
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OBJECTIVE The objective of this study was to examine the associations between insulin gene variable number of tandem repeats (INS VNTR) and insulin-like growth factor 1 (IGF1) gene promoter region polymorphisms with body composition in early childhood. METHODS This study was embedded in an ongoing prospective cohort study. Growth in early childhood (body mass index, total subcutaneous fat mas...
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